Regulation of the type I interferon response by chromatin organization (RNA-seq of L929 fibroblasts +/- SEV)
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × RNA_L929_CTRL vs 3 × RNA_L929_SEV4h vs 3 × RNA_L929_SEV8h vs 3 × RNA_L929_SEV16hGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Cohesin-mediated chromatin organization controls the differentiation and function of dendritic cellsScience immunology · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE277423_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1162147 and SRA study SRP533239. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8522268 RNA_L929_CTRL_01 RNA_L929_CTRL
- GSM8522269 RNA_L929_CTRL_02 RNA_L929_CTRL
- GSM8522270 RNA_L929_CTRL_03 RNA_L929_CTRL
- GSM8522271 RNA_L929_SEV4h_01 RNA_L929_SEV4h
- GSM8522272 RNA_L929_SEV4h_02 RNA_L929_SEV4h
- GSM8522273 RNA_L929_SEV4h_03 RNA_L929_SEV4h
- GSM8522274 RNA_L929_SEV8h_01 RNA_L929_SEV8h
- GSM8522275 RNA_L929_SEV8h_02 RNA_L929_SEV8h
- GSM8522276 RNA_L929_SEV8h_03 RNA_L929_SEV8h
- GSM8522277 RNA_L929_SEV16h_01 RNA_L929_SEV16h
- GSM8522278 RNA_L929_SEV16h_02 RNA_L929_SEV16h
- GSM8522279 RNA_L929_SEV16h_03 RNA_L929_SEV16h
- GSE270817 Regulation of the type I interferon response by chromatin organization (RNA-seq of HoxB8-FL pDC activation) 12 samples shares organization, interferon, chromatin, rna-seq, type
- GSE276734 3D Chromatin organization of signal-induced specific enhancers safeguards early ESC differentiation by promoting cluster gene expression [RNA-seq] 21 samples shares organization, chromatin, rna-seq
- GSE299090 H4K16ac contributes to chromatin compartment reorganization during mitotic and meiotic transitions [RNA-seq] 21 samples shares organization, chromatin, rna-seq
- GSE185673 RNA-Seq of lung fibroblasts of Atm defecient and wildtype mice. 15 samples shares fibroblasts, rna-seq, type
- GSE279025 cGAS deficient mice display premature aging associated with loss of chromatin organization, derepression of LINE1 elements and induction of inflammation [RNA-seq] 11 samples shares organization, chromatin, rna-seq
- GSE292285 Depletion of lamin-associated polypeptide 2 alpha leads to chromatin reorganization and redistribution of A-type lamins to open genomic regions [ChIP-seq] 22 samples shares organization, chromatin, type
- GSE228960 Bulk RNA-Seq from kidneys of uninephrectomized db/db mice as a model of severe diabetic kidney disease 28 samples shares sev, rna-seq
- GSE260900 Ancestral beta-globin gene haplotypes modify beta-thalassemia severity in a mouse model [Ery] 24 samples shares sev, type
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.