EMP1 preserves hematopoietic stem cell potential under homeostasis and radiation-induced injury by alleviating ER stress
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 22 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 22 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- EMP1 safeguards hematopoietic stem cells by suppressing sphingolipid metabolism and alleviating endoplasmic reticulum stressNature communications · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE277445_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1162428 and SRA study SRP533324. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 22 samples.
How we read this: 6 replicated groups read from 22 sample titles; they account for 22 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8522536 Emp1-fl-1 Emp1-fl
- GSM8522537 Emp1-fl-2 Emp1-fl
- GSM8522538 Emp1-fl-3 Emp1-fl
- GSM8522539 Emp1-ko-1 Emp1-ko
- GSM8522540 Emp1-ko-2 Emp1-ko
- GSM8522541 Emp1-ko-3 Emp1-ko
- GSM8522542 DMSO-1 DMSO
- GSM8522543 DMSO-2 DMSO
- GSM8522544 DMSO-3 DMSO
- GSM8522545 DMSO-4 DMSO
- GSM8522546 DMSO-5 DMSO
- GSM8522547 Tunicamycin-1 Tunicamycin
- GSM8522548 Tunicamycin-2 Tunicamycin
- GSM8522549 Tunicamycin-3 Tunicamycin
- GSM8522550 Tunicamycin-4 Tunicamycin
- GSM8522551 Tunicamycin-5 Tunicamycin
- GSM8522552 WT-1 WT
- GSM8522553 WT-2 WT
- GSM8522554 WT-3 WT
- GSM8522555 ER-1 E
- GSM8522556 ER-2 E
- GSM8522557 ER-3 E
- GSE277443 EMP1 preserves hematopoietic stem cell potential under homeostasis and radiation-induced injury by alleviating ER stress [ER-stress RNA-seq] 10 samples shares emp1, radiation-induced, hematopoietic, homeostasis, alleviating, preserves, potential, injury
- GSE326538 Aqueous Artemisia argyi extract mitigates acute lung injury by coordinating gut microbiota, metabolic homeostasis, and pulmonary inflammatory signaling 24 samples shares homeostasis, injury
- GSE295524 Unraveling the Temporal Dynamics of Radiation-Induced Lung Injury 18 samples shares radiation-induced, injury
- GSE331524 Transcriptomic analysis of hippocampus and prefrontal cortex in a mouse model of chronic radiation-induced gastrointestinal injury 12 samples shares radiation-induced, injury
- GSE261367 FLASH proton radiotherapy mitigates inflammatory and fibrotic pathways and preserves cardiac function in a preclinical mouse model of radiation-induced heart disease 11 samples shares radiation-induced, preserves
- GSE333173 Ketogenic Diet Alleviates Acute Radiation-Induced Intestinal Injury through JAK2/STAT3/RORγt/IL-17A Signaling Pathway via Gut Microbiome 9 samples shares radiation-induced, injury
- GSE303692 A plastic EMP1⁺ to LGR5⁺ cell state conversion as a therapeutic bypass to KRAS-G12D inhibition in metastatic colorectal cancer [RNA-Seq] 24 samples shares emp1
- GSE294258 Intracellular iron homeostasis-regulated epigenetic reprogramming contributes to -7/del(7q) leukemia 71 samples shares homeostasis
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.