Effects of tofacitinib and takinib on autoimmune pancreatitis in mice
RNA-seq (gene expression) · mouse · 14 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 14 samples: 5 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Dexamethasone's Clinical Efficacy in Experimental Autoimmune Pancreatitis Correlates with a Unique Transcriptomic Signature, Whilst Kinase Inhibitors Are Not EffectiveBiomedicines · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE277452_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1162460 and SRA study SRP533360. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 14 samples.
How we read this: 5 replicated groups read from 14 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8522648 Untreated control 1 Untreated control
- GSM8522649 Untreated control 2 Untreated control
- GSM8522650 Untreated control 3 Untreated control
- GSM8522651 Poly I:C-treated control 1 C-treated control
- GSM8522652 Poly I:C-treated control 2 C-treated control
- GSM8522653 Poly I:C-treated control 3 C-treated control
- GSM8522654 Tofacitinib treatment 1 Tofacitinib treatment
- GSM8522655 Tofacitinib treatment 2 Tofacitinib treatment
- GSM8522656 Tofacitinib treatment 3 Tofacitinib treatment
- GSM8522657 Takinib treatment 1 Takinib treatment
- GSM8522658 Takinib treatment 2 Takinib treatment
- GSM8522659 Takinib treatment 3 Takinib treatment
- GSM8522660 Dexamethasone treatment 1 Dexamethasone treatment
- GSM8522661 Dexamethasone treatment 2 Dexamethasone treatment
- GSE263577 Fecal microbiota transfer from autoimmune dry eye disease model mice to conventional mice induces ocular surface inflammation and stereotypic B cell receptor repertoire development in lacrimal gland 48 samples shares autoimmune
- GSE272687 12-Lipoxygenase Inhibition Suppresses Islet Immune and Inflammatory Responses and Delays Autoimmune Diabetes in Human Gene Replacement Mice. 16 samples shares autoimmune
- GSE305413 GM-CSF production by immune cells in steady state and autoimmune neuroinflammation mapped using fate-reporting mice 12 samples shares autoimmune
- GSE243623 BET inhibition rescues ciliogenesis and ameliorates pancreatitis-driven phenotypic changes in mice with Par3 loss 12 samples shares pancreatitis
- GSE247794 UVB exposure triggers autoimmune cutaneous inflammation in Foxp3dExon2-expressing mice. 12 samples shares autoimmune
- GSE268216 Dual specificity phosphatase 6 (DUSP6) deletion protects mice and reduces disease severity in autoimmune arthritis. 10 samples shares autoimmune
- GSE255890 An endosomal toll-like receptor inhibitor drug with therapeutic effects in autoimmune diseases 10 samples shares autoimmune
- GSE311286 Analysis of murine normal pancreatic organoids, pancreatitis-derived organoids, and PDAC organoids in complete media and of pancreatitis-derived organoids, and PDAC organoids cultured alone or cocultured with pancreatic stellate cells in reduced media 75 samples shares pancreatitis
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.