← BioTransfer GEO Dataset Finder
GEO series

Role of transglutaminase 2 in promoting biglycan synthesis in idiopathic gingival fibromatosis

GSE277572 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2024/09/24 Platform GPL16791
Summary
The mechanism of idiopathic gingival fibromatosis is still unclear. To provide new insights into the molecular and cellular differences between idiopathic gingival fibromatosis and periodontitis, we first identified the gene TGM2, which is differentially expressed between the two. We found that the expression of TGM2 is predominantly lower in idiopathic gingival fibromatosis than in periodontitis, and that the activity of SP1 due to the decreased expression of TGM2 promotes the generation of extracellular matrix-related genes in idiopathic gingival fibromatosis. We have identified biglycan, an extracellular matrix that is specifically upregulated in idiopathic gingival fibromatosis, and highlight the effects of SP1 and TGM2 on biglycan expression.
Published in
Role of transglutaminase 2 in promoting biglycan synthesis in idiopathic gingival fibromatosis
Ninomiya Y, Matsuda S, Suzuki S et al. · BMC oral health 2024 · PMID 39574071 · doi:10.1186/s12903-024-05211-8
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE277572_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1162834 and SRA study SRP533612. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 9 more — browse all 9 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.