GEO series
CDK4/6 inhibitors plus RANKL inhibitors in syngeneic TNBC model
GSE277614
Mus musculus
Expression profiling by high throughput sequencing
11 samples
2025/05/20
GPL28457
Summary
CDK4/6i alone have proven to be largely ineffective in breast cancer, even in the presence of functional retinoblastoma protein (pRB). In this study, we investigated the role of the RANK pathway in the response to CDK4/6i in pRB-proficient TNBC. Transcriptomic analysis of allografts revealed that combining CDK4/6i with RANKLi more effectively mounts an anti-tumoral immune response.
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