Role of endothelial STING1 in the transcriptional response to LPS
RNA-seq (gene expression) · mouse · 36 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 36 samples: 8 conditions, mostly with about 5 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Endothelial STING and STAT1 mediate IFN-independent effects of IL-6 in an endotoxemia-induced model of shockThe Journal of clinical investigation · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE277816_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1164258 and SRA study SRP534255. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 36 samples.
How we read this: 8 replicated groups read from 36 sample titles; they account for 36 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8531210 Endo_Tamoxifen_Saline1 Endo_Tamoxifen_Saline
- GSM8531211 Total_Tamoxifen_Saline1 Total_Tamoxifen_Saline
- GSM8531212 Endo_Tamoxifen_LPS1 Endo_Tamoxifen_LPS
- GSM8531213 Total_Tamoxifen_LPS1 Total_Tamoxifen_LPS
- GSM8531214 Endo_Tamoxifen_LPS2 Endo_Tamoxifen_LPS
- GSM8531215 Total_Tamoxifen_LPS2 Total_Tamoxifen_LPS
- GSM8531216 Endo_Tamoxifen_Saline2 Endo_Tamoxifen_Saline
- GSM8531217 Total_Tamoxifen_Saline2 Total_Tamoxifen_Saline
- GSM8531218 Endo_Oil_LPS1 Endo_Oil_LPS
- GSM8531219 Total_Oil_LPS1 Total_Oil_LPS
- GSM8531220 Endo_Oil_LPS2 Endo_Oil_LPS
- GSM8531221 Total_Oil_LPS2 Total_Oil_LPS
- GSM8531222 Endo_Tamoxifen_LPS3 Endo_Tamoxifen_LPS
- GSM8531223 Total_Tamoxifen_LPS3 Total_Tamoxifen_LPS
- GSM8531224 Endo_Tamoxifen_Saline3 Endo_Tamoxifen_Saline
- GSM8531225 Total_Tamoxifen_Saline3 Total_Tamoxifen_Saline
- GSM8531226 Endo_Oil_Saline3 Endo_Oil_Saline
- GSM8531227 Total_Oil_Saline3 Total_Oil_Saline
- GSM8531228 Endo_Tamoxifen_Saline4 Endo_Tamoxifen_Saline
- GSM8531229 Total_Tamoxifen_Saline4 Total_Tamoxifen_Saline
- GSM8531230 Endo_Oil_Saline4 Endo_Oil_Saline
- GSM8531231 Total_Oil_Saline4 Total_Oil_Saline
- GSM8531232 Endo_Oil_LPS4 Endo_Oil_LPS
- GSM8531233 Total_Oil_LPS4 Total_Oil_LPS
- GSM8531234 Endo_Tamoxifen_Saline5 Endo_Tamoxifen_Saline
- GSM8531235 Total_Tamoxifen_Saline5 Total_Tamoxifen_Saline
- GSM8531236 Endo_Oil_LPS5 Endo_Oil_LPS
- GSM8531237 Total_Oil_LPS5 Total_Oil_LPS
- GSM8531238 Endo_Oil_LPS6 Endo_Oil_LPS
- GSM8531239 Total_Oil_LPS6 Total_Oil_LPS
- GSM8531240 Endo_Tamoxifen_LPS6 Endo_Tamoxifen_LPS
- GSM8531241 Total_Tamoxifen_LPS6 Total_Tamoxifen_LPS
- GSM8531242 Endo_Tamoxifen_LPS7 Endo_Tamoxifen_LPS
- GSM8531243 Total_Tamoxifen_LPS7 Total_Tamoxifen_LPS
- GSM8531244 Endo_Tamoxifen_LPS8 Endo_Tamoxifen_LPS
- GSM8531245 Total_Tamoxifen_LPS8 Total_Tamoxifen_LPS
- GSE277696 Role of endothelial SOCS3 in the transcriptional response to LPS 45 samples shares lps, endothelial
- GSE201128 The response to lipopolysaccharide (LPS) of bone marrow derived macrophages treated with oxysterol binding protein (OSBP) inhibitors 30 samples shares lps
- GSE332798 Transcriptomic profiling of morphine and LPS exposure across mouse brain regions 208 samples shares lps
- GSE254687 PARK7/DJ-1 deficiency modulates microglial activation in response to LPS-induced inflammation 19 samples shares lps
- GSE250279 25-hydroxycholesterol mediates brain cytokine production and neutrophil infiltration in a mouse model of LPS-induced neuroinflammation. 40 samples shares lps
- GSE181641 Oxygen-dependent changes of gene expression in BMDM after LPS treatment 36 samples shares lps
- GSE290810 ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits [FACS_SpinalCord_Microglia & LPS_Brain_SpinalCord] 35 samples shares lps
- GSE300619 STAT1-dependent expression in kidney endothelium from mice challenged with LPS 32 samples shares lps
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.