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Transcriptomic profiling of Aurora Kinase B inhibition in lupus-prone mice

GSE277837 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2025/02/05 Platform GPL24247
Summary
Lupus nephritis (LN) is one of the most common and severe complications of systemic lupus erythematosus (SLE). Multitarget therapy (MT) has demonstrated a 20% higher rate of complete remission (CR) compared to conventional treatments for LN. Using a signature-based approach for drug repurposing, we identified and validated that the specific Aurora Kinase B (AURKB) inhibitor AZD1152 exhibits therapeutic efficacy comparable to that of MT therapy. To elucidate the therapeutic mechanism of AZD1152, we conducted transcriptome sequencing on renal tissues from MRL/lpr mice treated with AZD1152 and control vehicle. ,
Published in
Aurora kinase B inhibitor AZD1152: repurposing for treatment of lupus nephritis driven by the results of clinical trials
Zhao Y, Zheng Z, Jin X et al. · EBioMedicine 2025 · PMID 39799765 · doi:10.1016/j.ebiom.2024.105553
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Also filed as BioProject PRJNA1164299 and SRA study SRP534267. Searching any of these in the dataset finder brings you back here.

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