GEO series
Role of SREBP1 in chronic endometritis
GSE278134
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2025/05/08
GPL24247
Summary
The aim of this study was to investigate the role of SREBP1a in the regulation of inflammation in endometrial tissue after LPS injection. We report that systemic deletion of Srebf1, which encodes SREBP1, resulted in persistent endometrial inflammation and CD138-positive plasma cell infiltration. In addition, Srebf1 knockout mice exhibited pregnancy loss and placental insufficiency in the endometritis model.
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Paper (PMID 40539061) ↗
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