GEO series
A hierarchical Rorc(γt) cis-regulatory cascade orchestrates differentiation of RORγt⁺ innate immune cells [ATAC-seq]
GSE278157
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
40 samples
2026/03/24
GPL17021
Summary
Although ILC3s are known to differentiate in RORγt-dependent manner, besides ILC3s, RORγt-dependent developmental program is shared among several lymphocytes.However, little is known about the regulatory mechanism of RORγt expression specific to ILC3s. Our data newly idetified cell lineage-specific and two-step regulation of RORγt expression in ILC3 including LTi cells.
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Paper (PMID 41881028) ↗
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