← BioTransfer GEO Dataset Finder
GEO series

Transcriptomic analysis of human breast cancer cells upon carboplatin treatment

GSE278231 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/12/31 Platform GPL24676
Summary
Platinum drugs have broad spectrum and high anti-cancer activity with nucleus DNA as primary target. During platinum chemotherapeutics, the steady-state levels of reactive oxygen species (ROS) are generally elevated and induce oxidative stress response, to regulate cell survival and drug resistance. Currently, a novel nucleus-to-mitochondria ROS pathway has been identified. However, the pathways by which platinum drugs generate ROS, as well as the biological response, still lack systematic studies. Using carboplatin as an example, we systematically analysed the dynamic response to ROS in cancer cells.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE278231_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1166134 and SRA study SRP535284. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.