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Construction of immune profiles in PBMC of bacteremia mice with different outcomes

GSE278240 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2025/10/10 Platform GPL24247
Summary
We used mice as an experimental model to establish two animal infection models of bacteremia with different outcomes. In the low-dose infection group, the bacteria within the mice are cleared by the immune system, allowing the mice to survive. In contrast, the high-dose infection group leads to sepsis and ultimately results in the death of the mice. We aim to utilize single-cell sequencing technology to study the changes in the transcriptomes of various immune cells during different stages and outcomes of mammalian bacteremia, in order to understand the host's response to bacteremia.
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Direct links to NCBI, no account and no request form: the whole study as GSE278240_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 7 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1166165 and SRA study SRP535391. Searching any of these in the dataset finder brings you back here.

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