GEO series
IRE1alpha cancer mutants diiferentially regulate Rho family GTPases
GSE278307
Mus musculus
Expression profiling by high throughput sequencing
27 samples
2025/08/06
GPL21626
Summary
IRE1alpha is a multi-domain, ER-transmembrane protein that can mediate the Unfolded Protein Response (UPR). Here, we show that cancer-specific mutations in IRE1alpha can differentially activate the Rho family GTPases to mediate tumor promoting events in mouse keratinocytes.
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