Effect of an AAV1 containing an sh-RNA targeting Angptl2 on the hypocampus of male and female atherosclerotic mice
Single-nucleus RNA-seq · mouse · 12 samples
- What it is
- Single-nucleus RNA-seqGene activity measured in individual nuclei (used when whole cells are hard to isolate, for example from frozen tissue). Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Targeting angiopoietin like-2 positive senescent cells improves cognitive impairment in adult male but not female atherosclerotic LDLr(-/-);hApoB(100)(+/+) miceGeroScience · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE278331_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1166667 and SRA study SRP535475. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 12 more — browse all 12 samples with per-sample file links →
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- GSE312940 Granzyme B-mimicking nanozyme-containing nanovesicles for tumour-targeting delivery 6 samples shares containing, targeting
- GSE255078 RNAseq of proximal small intestine scrapings of mice fed a galactose, glucose, or lactose-containing diet during postweaning 39 samples shares containing
- GSE276418 Data Mining of IFNgamma-induced macrophage and Atherosclerotic Plaque Transcriptomes predicts a macrophage-specific role of STAT1 in human atherosclerosis 36 samples shares atherosclerotic
- GSE226479 Regulated and adaptive in vivo insulin secretion from islets only containing β-cells 22 samples shares containing
- GSE108069 RNA sequencing of a Spinocerebellar ataxia type 3 (SCA3) mouse model containing the full human ATXN3 gene with a repeat expansion of 75-80 CAGs II 22 samples shares containing
- GSE320220 microRNA146a suppresses pancreatitis via cross-talk with NF-kB and ASC-containing inflammasomes 20 samples shares containing
- GSE262695 Effects of Srsf3 deletion on gene expression and 3' UTR profiles in macrophages and atherosclerotic plaques [RNA-seq] 20 samples shares atherosclerotic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.