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Dickkopf-1 promotes tumor progression of gefitinib- resistant non-small cell lung cancer through cancer cell-fibroblast interactions

GSE278343 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/03/05 Platform GPL34284
Summary
Cancer cell-secreted proteins play a critical role in tumor progression and chemoresistance by influencing intercellular interactions within the tumor microenvironment. Investigating the intratumoral functions of these secretory proteins may provide insights into understanding and treating chemoresistant cancers. This study aims to identify potential anticancer target(s) in gefitinib-resistant non-small cell lung cancer (NSCLC), with a focus on secretory proteins and their effects on intercellular interactions. Here, we clarified that DKK1 mediates interactions between cancer cells and fibroblasts in gefitinib-resistant lung cancer, contributing to tumor progression.
Published in
Dickkopf-1 promotes tumor progression of gefitinib- resistant non-small cell lung cancer through cancer cell-fibroblast interactions
Choi M, Choi YJ, Lee YJ et al. · Experimental hematology & oncology 2025 · PMID 40025612 · doi:10.1186/s40164-025-00616-9
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Also filed as BioProject PRJNA1166686 and SRA study SRP535492. Searching any of these in the dataset finder brings you back here.

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