PPARG-centric transcriptional re-wiring during differentiation of human trophoblast stem cells into extravillous trophoblasts [ChIP-seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 15 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 15 samples: 6 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- PPARG-centric transcriptional re-wiring during differentiation of human trophoblast stem cells into extravillous trophoblastsNucleic acids research · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE295569_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1255193 and SRA study SRP581074. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 14 samples.
How we read this: 6 replicated groups read from 15 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8952991 EVTd2_PPARG_rep1 EVTd2_PPARG
- GSM8952992 EVTd2_PPARG_rep2 EVTd2_PPARG
- GSM8952993 EVTd4_PPARG_rep1 EVTd4_PPARG
- GSM8952994 EVTd4_PPARG_rep2 EVTd4_PPARG
- GSM8952995 EVTd6_PPARG_rep1 EVTd6_PPARG
- GSM8952996 EVTd6_PPARG_rep2 EVTd6_PPARG
- GSM8952997 EVTd8_PPARG_rep1 EVTd8_PPARG
- GSM8952998 EVTd8_PPARG_rep2 EVTd8_PPARG
- GSM8952999 TSC_PPARG_rep1 TSC_PPARG
- GSM8953000 TSC_PPARG_rep2 TSC_PPARG
- GSM8953001 Input_EVTd2 Input_EVTd
- GSM8953002 Input_EVTd4 Input_EVTd
- GSM8953003 Input_EVTd6 Input_EVTd
- GSM8953004 Input_EVTd8 Input_EVTd
- GSM8953005 Input_TSC
- GSE278374 PPARG-centric transcriptional re-wiring during differentiation of human trophoblast stem cells into extravillous trophoblasts [ChIP-seq] 44 samples shares pparg-centric, extravillous, trophoblasts, trophoblast, re-wiring, chip-seq, stem
- GSE278375 PPARG-centric transcriptional re-wiring during differentiation of human trophoblast stem cells into extravillous trophoblasts [RNA-seq] 32 samples shares pparg-centric, extravillous, trophoblasts, trophoblast, re-wiring, stem
- GSE236794 Specificity protein 6 governs human cytotrophoblast fate decisions and trophoblast stem cell establishment by targeting MSX2 regulatory elements [ChIP-seq] 20 samples shares trophoblast, chip-seq, stem
- GSE266194 Ectopic expression of DNMT3L in human trophoblast stem cells restores features of the placental methylome [ChIP-seq] 15 samples shares trophoblast, chip-seq, stem
- GSE243579 iPSC-based modeling of preeclampsia identifies defects in extravillous trophoblast differentiation 144 samples shares extravillous, trophoblast
- GSE276594 Hypoxia and loss of GCM1 expression prevents differentiation and contact inhibition in human trophoblast stem cells [RNA-Seq 2] 45 samples shares trophoblast, stem
- GSE276595 Hypoxia and loss of GCM1 expression prevents differentiation and contact inhibition in human trophoblast stem cells [RNA-Seq I] 26 samples shares trophoblast, stem
- GSE306221 Transient inhibition of MEK/ERK and WNT pathways enhances direct differentiation of primed hPSCs into functional trophoblast stem cells 18 samples shares trophoblast, stem
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.