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Gene expression profile at single cell level of lung alveolar macrophages (AM) and interstital macrophages (IM) in MMTV-HER2 and wildtype early stage (16-week) or late stage (32-week) mice.

GSE278454 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/10/01 Platform GPL24247
Summary
Disseminated cancer cells reside in the lung alveolar niche where they are exposed to interactions with alveolar macrophages. Here we report singe-cell RNA-sequencing data of lung macrophages from MMTV-HER2 mice at the early stage (16-weeks) harboring single dormant cancer cells and late stage mice (32-weeks harboring metastatic lesions, as well as wildtype control mice. We discovered alveolar macrophage and interstitial macrophage subsets that change in expression profile and frequency between stages. We find majority of the AMs are homeostatic in phenotype, and emergence of inflammatory AM subsets in late-stage MMTV-HER2 mice.
Published in
Lung-resident alveolar macrophages regulate the timing of breast cancer metastasis
Dalla E, Papanicolaou M, Park MD et al. · Cell 2024 · PMID 39378878 · doi:10.1016/j.cell.2024.09.016
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Also filed as BioProject PRJNA1169196 and SRA study SRP536815. Searching any of these in the dataset finder brings you back here.

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