Auto-inhibition of PRC2 by the broadly expressed long isoform of AEBP2.
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 59 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 59 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Auto-inhibition of PRC2 by the broadly expressed long isoform of AEBP2The EMBO journal · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE217538_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA899502 and SRA study SRP406854. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 59 more — browse all 59 samples with per-sample file links →
- GSE310209 Opposing functions of AEBP2 isoforms fine-tune PRC2 catalytic activity 72 samples shares aebp2, prc2, isoform
- GSE223666 Alternative splicing decouples local from global PRC2 activity 87 samples shares prc2
- GSE239638 Cancer-associated Histone H3 N-terminal arginine mutations disrupt PRC2 activity and impair differentiation 79 samples shares prc2
- GSE298615 Decoding PRC2 stage-specific roles during germline-embryo-germline transition 62 samples shares prc2
- GSE55698 Variant PRC1 complex dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation 41 samples shares prc2
- GSE263938 Chromatin repression by PRC2 results in reduced gene expression driving key features of CD8 T cell exhaustion 34 samples shares prc2
- GSE298716 The transcriptional repressor AEBP2 is indispensable for the epigenetic control of mimetic thymic epithelial cell differentiation and central self-tolerance induction. 28 samples shares aebp2
- GSE249591 Gene suppression by PRC2 enhances the gene inductions by Aire and the development of mimetic cell populations 572 samples shares prc2
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.