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Effect of the rhesus theta defensin-1 (RTD-1) on gene expression in human monocytes. [II]

GSE278568 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/12/09 Platform GPL18573
Summary
Rhesus theta defensin (RTD)-1, a cyclic antimicrobial peptide, regulates gene expression and immune signaling pathways in cell culture and animal models of immune mediated diseases. To gain insights into RTD-1 regulation of naïve cells, we performed RNA sequencing (RNA-seq) to determine the effect of RTD-1 on global gene expression in human monocytes. Analysis of differentially expressed genes revealed RTD-1 mediated stimulation of interferon and antiviral gene expression pathways in human monocytes.
Published in
The macrocyclic peptide rhesus theta defensin 1 activates interferon and antiviral pathways in human monocytes
Tongaonkar P, Trinh KK, Henley JE et al. · Journal of leukocyte biology 2025 · PMID 41139211 · doi:10.1093/jleuko/qiaf150
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Also filed as BioProject PRJNA1167793 and SRA study SRP536109. Searching any of these in the dataset finder brings you back here.

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