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The regulatory effect of IRF8 on the gene expression profiles of bone marrow derived dendritic cells

GSE278890 Mus musculus Expression profiling by high throughput sequencing 5 samples Submitted 2024/10/10 Platform GPL24247
Summary
To investigate the role of IRF8 in the inflammatory microenvironment of abdominal aortic aneurysm tissue, bone marrow cells were isolated from the tibias and femurs of 8-week-old male mice and cultured with granulocyte-macrophage colony-stimulating factor and Flt3L cytokines to generate CD103-positive dendritic cells. Cells were harvested on days 9 and 15-16 and stimulated with tumor necrosis factor-alpha. Gene ontology analysis revealed upregulation of T cell activation and chemotaxis in bone marrow-derived dendritic cells from IRF8 overexpression mice, indicating IRF8's role in dendritic cell-T cell interactions. Protein-protein interaction analysis highlighted Cd40 and Fcgr1 as key surface markers. IRF8-related genes were enriched in type I interferon signaling pathways, implicating IRF8 in antigen presentation functions of dendritic cells.
Published in
IRF8 Drives Conventional Type 1 Dendritic Cell Differentiation and CD8(+) T Cell Activation to Aggravate Abdominal Aortic Aneurysm Development
Yuan Z, Shu L, Zheng Y et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 · PMID 40184622 · doi:10.1002/advs.202416238
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Also filed as BioProject PRJNA1169369 and SRA study SRP536811. Searching any of these in the dataset finder brings you back here.

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