Non-classical action of Ku70 promotes Treg suppressive function through a FOXP3-dependent mechanism in lung adenocarcinoma
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 12 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 2 × WT Treg, Foxp3, vs 2 × KO Treg, Foxp3, vs 2 × WT Tconv, Ku70, vs 2 × WT Treg, Ku70,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Nonclassical action of Ku70 promotes Treg-suppressive function through a FOXP3-dependent mechanism in lung adenocarcinomaThe Journal of clinical investigation · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE278950_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1169822 and SRA study SRP536978. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 8 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 8 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8558465 WT Treg, Input
- GSM8558466 WT Treg, Foxp3, rep1 WT Treg, Foxp3,
- GSM8558467 WT Treg, Foxp3, rep2 WT Treg, Foxp3,
- GSM8558468 KO Treg, Input
- GSM8558469 KO Treg, Foxp3, rep1 KO Treg, Foxp3,
- GSM8558470 KO Treg, Foxp3, rep2 KO Treg, Foxp3,
- GSM8558471 Tconv, Input
- GSM8558472 WT Tconv, Ku70, rep1 WT Tconv, Ku70,
- GSM8558473 WT Tconv, Ku70, rep2 WT Tconv, Ku70,
- GSM8558474 Treg, Input
- GSM8558475 WT Treg, Ku70, rep1 WT Treg, Ku70,
- GSM8558476 WT Treg, Ku70, rep2 WT Treg, Ku70,
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- GSE330245 GATA4 loss promotes mutant Kras-driven pancreatic ductal adenocarcinoma in the absence of canonical precursor lesions [Epithelial RNA-seq] 12 samples shares adenocarcinoma, promotes
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.