Kras loss of heterozygosity promotes MAPK dependent pancreatic ductal adenocarcinoma and induces therapeutic sensitivity
RNA-seq (gene expression) · mouse · 31 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 31 samples: 6 conditions, mostly with about 5 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- KRAS Loss of Heterozygosity Promotes MAPK-Dependent Pancreatic Ductal Adenocarcinoma Initiation and Induces Therapeutic Sensitivity to MEK InhibitionCancer research · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE277392_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1162093 and SRA study SRP533312. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 31 samples.
How we read this: 6 replicated groups read from 31 sample titles; they account for 31 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8521561 KPCf Pancreas Veh Rep1 KPCf Pancreas Veh
- GSM8521562 KPCf Pancreas Veh Rep2 KPCf Pancreas Veh
- GSM8521563 KPCf Pancreas Veh Rep3 KPCf Pancreas Veh
- GSM8521564 KPCf Pancreas Veh Rep4 KPCf Pancreas Veh
- GSM8521565 KPCf Pancreas Veh Rep5 KPCf Pancreas Veh
- GSM8521566 KPCf Pancreas AZD6244 Rep1 KPCf Pancreas AZD6244
- GSM8521567 KPCf Pancreas AZD6244 Rep2 KPCf Pancreas AZD6244
- GSM8521568 KPCf Pancreas AZD6244 Rep3 KPCf Pancreas AZD6244
- GSM8521569 KPCf Pancreas AZD6244 Rep4 KPCf Pancreas AZD6244
- GSM8521570 KPCf Pancreas AZD6244 Rep5 KPCf Pancreas AZD6244
- GSM8521571 KPC Pancreas Rep1 KPC Pancreas
- GSM8521572 KPC Pancreas Rep2 KPC Pancreas
- GSM8521573 KPC Pancreas Rep3 KPC Pancreas
- GSM8521574 KPC Pancreas Rep4 KPC Pancreas
- GSM8521575 KPC Pancreas Rep5 KPC Pancreas
- GSM8521576 KPCf Pancreas Rep1 KPCf Pancreas
- GSM8521577 KPCf Pancreas Rep2 KPCf Pancreas
- GSM8521578 KPCf Pancreas Rep3 KPCf Pancreas
- GSM8521579 KPCf Pancreas Rep4 KPCf Pancreas
- GSM8521580 KPCf Pancreas Rep5 KPCf Pancreas
- GSM8521581 KPCf Pancreas Rep6 KPCf Pancreas
- GSM8521582 KPC Pancreas Tum Veh Rep1 KPC Pancreas Tum Veh
- GSM8521583 KPC Pancreas Tum Veh Rep2 KPC Pancreas Tum Veh
- GSM8521584 KPC Pancreas Tum Veh Rep3 KPC Pancreas Tum Veh
- GSM8521585 KPC Pancreas Tum Veh Rep4 KPC Pancreas Tum Veh
- GSM8521586 KPC Pancreas Tum Veh Rep5 KPC Pancreas Tum Veh
- GSM8521587 KPC Pancreas Tum AZD6244 Rep1 KPC Pancreas Tum AZD6244
- GSM8521588 KPC Pancreas Tum AZD6244 Rep2 KPC Pancreas Tum AZD6244
- GSM8521589 KPC Pancreas Tum AZD6244 Rep3 KPC Pancreas Tum AZD6244
- GSM8521590 KPC Pancreas Tum AZD6244 Rep4 KPC Pancreas Tum AZD6244
- GSM8521591 KPC Pancreas Tum AZD6244 Rep5 KPC Pancreas Tum AZD6244
- GSE269680 CDK8 remodels the tumor microenvironment to resist the therapeutic efficacy of targeted KRASG12D inhibition in pancreatic ductal adenocarcinoma (spatial) 15 samples shares adenocarcinoma, therapeutic, pancreatic
- GSE307773 Oncogenic MAPK signalling induces epithelial cell state change and therapeutic resistance in vivo [RNA-Seq] 175 samples shares mapk, therapeutic
- GSE234245 Multiomic Profile Integration Reveals Early Signatures of Amyotrophic Lateral Sclerosis and Suggests the MAPK Pathway as a Therapeutic Target [RNA-Seq] 79 samples shares mapk, therapeutic
- GSE278577 β2 ADRENERGIC SIGNALING STIMULATES EARLY IL-1β SECRETION IN MACROPHAGES BY INDUCING MAPK-DEPENDENT Il1b TRANSCRIPTION [RNA-Seq] 30 samples shares mapk, dependent
- GSE307774 Oncogenic MAPK signalling induces epithelial cell state change and therapeutic resistance in vivo [scRNA-Seq] 29 samples shares mapk, therapeutic
- GSE302629 Loss of tumor cell MHC Class II drives MAPK-inhibitor insensitivity of BRAF-mutant anaplastic thyroid cancers [RNA-seq] 24 samples shares mapk, sensitivity
- GSE342169 Cysteine and Glycine Rich Protein 3 (Csrp3) modulates cardiomyocyte mitotic cell cycle entry through Ring Finger Protein 5 (Rnf5)/p38 MAPK dependent pathway 12 samples shares mapk, dependent
- GSE234246 Multiomic Profile Integration Reveals Early Signatures of Amyotrophic Lateral Sclerosis and Suggests the MAPK Pathway as a Therapeutic Target 158 samples shares mapk, therapeutic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.