Concomitant loss of TET2 and TET3 results in T cell expansion and genomic instability
RNA-seq (gene expression) · mouse · 31 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 31 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Concomitant loss of TET2 and TET3 results in T cell expansion and genomic instability in miceCommunications biology · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE279236_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1171448 and SRA study SRP349374. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 31 more — browse all 31 samples with per-sample file links →
- GSE190226 Concomitant loss of TET2 and TET3 results in T cell expansion and genomic instability [BGI-RNA-Seq] 21 samples shares tet2, tet3, concomitant, instability, expansion, results, loss
- GSE278239 Concomitant loss of TET2 and TET3 results in T cell expansion and genomic instability 6 samples shares tet2, tet3, concomitant, instability, expansion, results, loss
- GSE266580 Ablation of Id1 Reduces Clonal Hematopoiesis, Genomic Instability and Delays Leukemia in Mice with Tet2 Loss of Function [RNA-seq] 12 samples shares tet2, instability, loss
- GSE151211 Tet2 and Tet3 functionally overlap in vitamin C-induced epigenomic alterations in acute myeloid leukemia 49 samples shares tet2, tet3
- GSE190231 Assessing the impact of TET2 and TET3 deletion in TCRa and TCRb expression and repertoire in murine CD4 T cells in physiological and pathological conditions 22 samples shares tet2, tet3
- GSE190229 Assessing the impact of TET2 and TET3 deletion in TCRa and TCRb expression and repertoire in murine CD4 T cells in physiological and pathological conditions [TCR-SEQ] 18 samples shares tet2, tet3
- GSE254998 Loss of TET2 increases B-1 cell number and IgM production while limiting CDR3 diversity 21 samples shares tet2, loss
- GSE27816 Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation 14 samples shares tet2, loss
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.