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N6-methyladenosine and the NEXT complex direct Xist RNA turnover and X inactivation dynamics

GSE279269 Mus musculus (mouse) DNA methylation 147 samples Submitted 2025/06/19 Platform GPL19057
At a glance

DNA methylation · mouse · 147 samples

What it is
DNA methylationChemical marks on DNA that help switch genes on or off.
Organism
Mus musculus (mouse)
Samples
147 samples: 120 distinct titles, 26 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
m(6)A and the NEXT complex direct Xist RNA turnover and X-inactivation dynamicsNature structural & molecular biology · 2025
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
Published in
m(6)A and the NEXT complex direct Xist RNA turnover and X-inactivation dynamics
Wei G, Coker H, Rodermund L et al. · Nature structural & molecular biology 2025 · PMID 40926104 · doi:10.1038/s41594-025-01663-w
This dataset
Open GSE279269 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE279269_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: Look for beta-value tables or raw IDAT files among the supplementary files.

Also filed as BioProject PRJNA1171761 and SRA study SRP537910. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 40926104) ↗
Study design
120 distinct titles, 26 of them repeated
C7H8_Ctrl ×3 METTL3_FKBP12^F36V, C3 clone, ×2 METTL3_FKBP12^F36V, C3 clone, dTAG 26h, ×2 METTL3_FKBP12^F36V, H5 clone, ×2 METTL3_FKBP12^F36V, H5 clone, dTAG 26h, ×2 METTL3_FKBP12^F36V, 12D clone, Ctrl, 0min, ×2 METTL3_FKBP12^F36V, 12D clone, Ctrl, 90min, ×2 METTL3_FKBP12^F36V, 12D clone, Ctrl, 180min, ×2 +18 more

How we read this: Read from 147 sample titles: 120 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 107 more — browse all 147 samples with per-sample file links →

Datasets on a similar topic

Search all mouse RNA-seq datasets in GEO →

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