NAD+ - and EVA1-C-dependent reversal of neurological deficits is mediated by differential alternative RNA splicing in tauopathic animal models
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 4 × WT vs 4 × WT_N vs 4 × Tau vs 4 × Tau_NGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- NAD(+) reverses Alzheimer's neurological deficits via regulating differential alternative RNA splicing of EVA1CScience advances · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE279334_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1171884 and SRA study SRP538025. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8567452 WT1 WT
- GSM8567453 WT2 WT
- GSM8567454 WT3 WT
- GSM8567455 WT4 WT
- GSM8567456 WT_NR1 WT_N
- GSM8567457 WT_NR2 WT_N
- GSM8567458 WT_NR3 WT_N
- GSM8567459 WT_NR4 WT_N
- GSM8567460 Tau1 Tau
- GSM8567461 Tau2 Tau
- GSM8567462 Tau3 Tau
- GSM8567463 Tau4 Tau
- GSM8567464 Tau_NR1 Tau_N
- GSM8567465 Tau_NR2 Tau_N
- GSM8567466 Tau_NR3 Tau_N
- GSM8567467 Tau_NR4 Tau_N
- GSE310453 Functional divergence of Capicua isoforms explains differential tissue vulnerability in neurological disease 70 samples shares neurological, differential
- GSE270710 Tet2-mediated clonal hematopoiesis improves neurological deficits and is associated with inflammation resolution in the subacute phase of stroke 12 samples shares neurological, deficits
- GSE330309 Impact of Sex Chromosomes and Gonad Type in Stress Susceptibility in Corticostriatal Brain Regions 96 samples shares nad
- GSE291544 Roles of chromosomal and gonadal sex in the fetal and placental responses to maternal food restriction in mice [junctional zone/decidua] 60 samples shares nad
- GSE300533 Gonadal and chromosomal sex effects on hepatic transcriptome 48 samples shares nad
- GSE261869 NAD+ prevents chronic kidney disease by activating renal tubular metabolism - bulk RNA-sequencing 32 samples shares nad
- GSE173532 Altering metabolism to program cell identity via NAD+ dependent deacetylation [RNA-seq] 30 samples shares nad
- GSE334551 NAD+ Deficiency Drives Metabolic Dysfunction-Associated Atrial Fibrillation 29 samples shares nad
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.