CITCO is a non-genotoxic hepatocarcinogen in humanised constitutive androstane receptor mice but not in wild-type animals
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × CITTO_WT vs 3 × CITCO_hCA vs 3 × CITCO_CarKO vs 3 × CornOil_WTGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The potent human CAR activator CITCO is a non-genotoxic hepatic tumour-promoting agent in humanised constitutive androstane receptor mice but not in wild-type animalsArchives of toxicology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE279414_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1172669 and SRA study SRP538431. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8569561 CITTO_WT1 CITTO_WT
- GSM8569562 CITCO_hCAR1 CITCO_hCA
- GSM8569563 CITCO_CarKO1 CITCO_CarKO
- GSM8569564 CornOil_WT1 CornOil_WT
- GSM8569565 CITTO_WT2 CITTO_WT
- GSM8569566 CITCO_hCAR2 CITCO_hCA
- GSM8569567 CITCO_CarKO2 CITCO_CarKO
- GSM8569568 CornOil_WT2 CornOil_WT
- GSM8569569 CITTO_WT3 CITTO_WT
- GSM8569570 CITCO_hCAR3 CITCO_hCA
- GSM8569571 CITCO_CarKO3 CITCO_CarKO
- GSM8569572 CornOil_WT3 CornOil_WT
- GSE314547 Estradiol disrupts constitutive androstane receptor (CAR)-mediated bile acid homeostasis in a murine model of intrahepatic cholestasis of pregnancy (ICP), and this effect is reversed by CAR ligands 16 samples shares constitutive, androstane, receptor
- GSE262786 MI-883 Constitutes a Novel Dual-Action Ligand Targeting Constitutive Androstane Receptor and Pregnane X Receptor for Hypercholesterolemia Intervention 10 samples shares constitutive, androstane, receptor
- GSE283511 Constitutive androstane receptor in macrophages regulates Toll-like receptor 4-mediated innate immune responses during endotoxemic liver injury 6 samples shares constitutive, androstane, receptor
- GSE271536 Constitutive Epidermal Osteopontin Expression in Osteopontin-Null Mice Develop Ultraviolet B-Induced Cutaneous Squamous Cell Carcinomas Comparable to Wild-Type Mice 18 samples shares constitutive, wild-type
- GSE246914 Genomic and Transcriptomic Analyses of Chemical Hepatocarcinogenesis Aggravated by Loss of Oncoproteins in Hepatocytes [RNA-Seq] 105 samples shares hepatocarcinogen
- GSE289016 Graded constitutive NF-κB signaling in B cells drives SLL/CLL-like lymphomagenesis and overcomes microenvironment dependence [M002] 35 samples shares constitutive
- GSE289013 Graded constitutive NF-κB signaling in B cells drives SLL/CLL-like lymphomagenesis and overcomes microenvironment dependence 32 samples shares constitutive
- GSE322844 Caffeine in the context of sorafenib chemotherapy: Insights from experimental hepatocarcinogenesis 25 samples shares hepatocarcinogen
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.