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Transcriptional profiling of liver obtained from a mouse model for metabolic dysfunction-associated steatotic liver disease

GSE279512 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/01/20 Platform GPL24247
Summary
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent hepatic disorder worldwide and closely associated with type 2 diabetes mellitus (T2DM). The pathogenesis of MASLD is multifaceted and its treatment options are very limited. Consequently, it is urgent to identify novel therapeutic targets and develop effective treatment strategies. RNA sequencing analysis was performed to understand the transcriptomic changes in a mouse model of MASLD.
Published in
ALOX15 Aggravates Metabolic Dysfunction-Associated Steatotic Liver Disease in Mice with Type 2 Diabetes via Activating the PPARγ/CD36 Axis
Yan W, Cui X, Guo T et al. · Antioxidants & redox signaling 2025 · PMID 39815992 · doi:10.1089/ars.2024.0670
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Direct links to NCBI, no account and no request form: the whole study as GSE279512_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1173164 and SRA study SRP538674. Searching any of these in the dataset finder brings you back here.

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