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PHLDA2 promotes breast cancer metastasis by increasing extracellular matrix deposition and vascular permeability

GSE279530 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2026/08/01 Platform GPL24676
Summary
There is a critical need to define drivers of metastasis in order to identify novel drug targets and improve patient prognosis. These are particularly necessary for receptor negative Triple Negative Breast Cancer (TNBC) for which there are no targeted therapy options. Our previous work identified a potential breast cancer metastasis promoting gene known as Pleckstrin-Homology like Protein 2, PHLDA2. In this study, we define the novel role of PHLDA2 as a pro-metastatic gene in TNBC and investigate its mechanism. Bulk sequencing of TNBC cells overexpressing PHLDA2 reveal upregulation of genes related to cell migration, extracellular matrix deposition, and vascular permeability. We validate these bulk sequencing results using in vitro and in situ assays.
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Also filed as BioProject PRJNA1173201 and SRA study SRP538727. Searching any of these in the dataset finder brings you back here.

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