BCR::ABL1-induced enhancer reprogramming uncovers hypersensitivity of Ph+B-ALL cells to enhancer-targeting drugs [ChIP-Seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 91 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Topic
- Acute lymphoblastic leukemiaThis series is part of our curated briefing on it.
- Samples
- 91 samples: 70 distinct titles, 16 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- BCR::ABL1-Induced Enhancer Reprogramming Uncovers Hypersensitivity of Ph+B-ALL Cells to Enhancer-Targeting DrugsAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE279644_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1173753 and SRA study SRP538975. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 91 sample titles: 70 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8577378 SUPB15_DMSO_H3K27ac_ChIP
- GSM8577379 SUPB15_DMSO_IgG_ChIP
- GSM8577380 SUPB15_DMSO_input
- GSM8577381 SUPB15_PON_H3K27ac_ChIP
- GSM8577382 SUPB15_PON_IgG_ChIP
- GSM8577383 SUPB15_PON_input
- GSM8577384 TOM1_DMSO_H3K27ac_ChIP
- GSM8577385 TOM1_DMSO_IgG_ChIP
- GSM8577386 TOM1_DMSO_input
- GSM8577387 TOM1_PON_H3K27ac_ChIP
- GSM8577388 TOM1_PON_IgG_ChIP
- GSM8577389 TOM1_PON_input
- GSM8577390 BAL08_DMSO_H3K27ac_ChIP
- GSM8577391 BAL08_DMSO_IgG_ChIP
- GSM8577392 BAL08_PON_H3K27ac_ChIP
- GSM8577393 BAL08_PON_IgG_ChIP
- GSM8577394 BAL05_H3K27ac_ChIP
- GSM8577395 BAL05_IgG_ChIP
- GSM8577396 BAL11_H3K27ac_ChIP
- GSM8577397 BAL11_IgG_ChIP
- GSM8577398 BV173_parental_DMSO_H3K27ac_ChIP
- GSM8577399 BV173_parental_DMSO_IgG_ChIP
- GSM8577409 BA_p190_DMSO_H3K27ac_rep1
- GSM8577410 BA_p190_DMSO_H3K27ac_rep2
- GSM8577411 BA_p190_DMSO_H3K27ac_rep3
- GSM8577412 BA_p190_DMSO_IgG
- GSM8577413 BA_p190_PON_H3K27ac_rep1
- GSM8577414 BA_p190_PON_H3K27ac_rep2
- GSM8577415 BA_p190_PON_H3K27ac_rep3
- GSM8577416 EV_D3_H3K27ac_rep1
- GSM8577417 EV_D3_H3K27ac_rep2
- GSM8577418 EV_D3_H3K27ac_rep3
- GSM8577419 EV_D3_IgG
- GSM8577420 BCR_D60_rep1
- GSM8577421 BCR_D60_rep2
- GSM8577422 BCR_D60_rep3
- GSM8577423 BCR_D7_input
- GSM8577424 EV_D7_input
- GSM8577425 EV_D7_rep1
- GSM8577426 EV_D7_rep2
+ 51 more — browse all 91 samples with per-sample file links →
- GSE193713 Genome-wide maps of chromatin state for histone modifications and chromatin remodeling factors in WT and PHF6-KO conditions in Jurkat T-ALL cells. 20 samples same disease briefing
- GSE13425 Expression data from ALL patients included in the set used to construct a classification signature (COALL cohort) 190 samples same disease briefing
- GSE12995 Expression data for diagnosis acute lymphoblastic leukemia samples 175 samples same disease briefing
- GSE160298 The chromatin accessibility landscape of T-Cell Acute Lymphoblastic Leukemia 80 samples same disease briefing
- GSE154675 PHF6 Interacts with LMO2 During Normal Haematopoiesis and in Leukaemia and Regulates the Level of Gene Expression and Genome Integrity 41 samples same disease briefing
- GSE115656 Alternative splicing analysis of pediatric B-cell acute lymphoblastic leukemia compared to normal bone marrow derived pro-B cells 38 samples same disease briefing
- GSE18198 Expression profile of human T-ALL cell lines treated with DMSO or SAHM1 12 samples same disease briefing
- GSE279594 BCR::ABL1-induced enhancer reprogramming uncovers hypersensitivity of Ph+B-ALL cells to enhancer-targeting drugs [RNA-Seq] 52 samples shares b-all, bcr, enhancer-targeting, hypersensitivity, reprogramming, abl1-induced, enhancer, uncovers
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.