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CMTR1 regulates hippocampus-dependent memory consolidation and long-term synaptic plasticity by promoting NMDA-receptor signaling

GSE279686 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2025/08/06 Platform GPL24247
Summary
Eukaryotic mRNA is 5'-end capped with m7 guanosine, forming the cap0 (m7GpppNpNp, N: any nucleotide). Cap methyltransferase (CMTR1) further catalyzes 2'-O-ribose methylation of the first transcribed nucleotide (N1 2'-O-Me) to produce the cap1 (m7GpppNmNp) structure in all eukaryotes except yeasts. To elucidate the molecular changes in the hippocampus caused by the deletion of CMTR1 in Emx1-lineage cells, hippocampal tissues from CMTR1-cWT and cKOEmx1 mice were processed for RNA-sequencing analysis.
Published in
CMTR1-catalyzed 2'-O-methylation promotes NMDA receptor signaling, long-term potentiation and memory
Azeem S, Chang TT, Peng C et al. · Progress in neurobiology 2025 · PMID 40571183 · doi:10.1016/j.pneurobio.2025.102802
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Also filed as BioProject PRJNA1174091 and SRA study SRP539106. Searching any of these in the dataset finder brings you back here.

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