Small molecule-based regulation of gene expression in human astrocytes switching on and off the G-quadruplex control systems
RNA-seq (gene expression) · human · 15 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 15 samples: 15 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Small molecule-based regulation of gene expression in human astrocytes switching on and off the G-quadruplex control systemsThe Journal of biological chemistry · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE279752_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1174205 and SRA study SRP539218. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 15 sample titles: 15 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8579651 Control - 1 - age 32
- GSM8579652 Control - 2 - age 32
- GSM8579653 Control - 3 - age 32
- GSM8579654 Control - 4 - age 32
- GSM8579655 Control - 5 - age 32
- GSM8579656 PDS - 1 - age 32
- GSM8579657 PDS - 2 - age 32
- GSM8579658 PDS - 3 - age 32
- GSM8579659 PDS - 4 - age 32
- GSM8579660 PDS - 5 - age 32
- GSM8579661 PhpC - 1 - age 32
- GSM8579662 PhpC - 2 - age 32
- GSM8579663 PhpC - 3 - age 32
- GSM8579664 PhpC - 4 - age 32
- GSM8579665 PhpC - 5 - age 32
- GSE330903 Depleting prion protein using splice-switching small molecules 31 samples shares switching, small
- GSE237669 A single small molecule-based human embryo model reveals V-ATPase requirement in mammalian blastocyst cavitation 18 samples shares molecule-based, small
- GSE236961 A single small molecule-based human embryo model reveals a requirement for V-ATPase in mammalian blastocyst cavitation 18 samples shares molecule-based, small
- GSE307272 Age-associated G-quadruplex accumulation and DDX5 loss shape chromatin landscapes in human astrocytes [RNA-seq] 10 samples shares g-quadruplex, astrocytes
- GSE280939 Discovery of a small-size imidazole-benzoindolium ligand for binding to KRAS promoter G-quadruplex that inhibits cancer growth with enhanced immunomodulation 6 samples shares g-quadruplex, small
- GSE261837 Optical control of gene expression using a DNA G-quadruplex targeting reversible photoswitch 55 samples shares g-quadruplex, control
- GSE296647 Indirect identification of genomic G-quadruplexes via a small protein probe that specifically recognizes C-rich single-stranded DNA 24 samples shares g-quadruplex, small
- GSE307274 Age-associated G-quadruplex accumulation and DDX5 loss shape chromatin landscapes in human astrocytes [CUT&Tag] 16 samples shares g-quadruplex, astrocytes
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.