FOXP2 expression was decreased in placental tissue sample of patients with preeclampsia compared with healthy pregnant women
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 6 × N vs 6 × PEGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- FOXP2 overexpression upregulates LAMA4 expression and thereby alleviates preeclampsia by regulating trophoblast behaviorCommunications biology · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE279757_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1174213 and SRA study SRP539224. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 2 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8579735 N1 N
- GSM8579736 N2 N
- GSM8579737 N3 N
- GSM8579738 N4 N
- GSM8579739 N5 N
- GSM8579740 N6 N
- GSM8579741 PE1 PE
- GSM8579742 PE2 PE
- GSM8579743 PE3 PE
- GSM8579744 PE4 PE
- GSM8579745 PE5 PE
- GSM8579746 PE6 PE
- GSE303840 Racial discrepancies in placental gene expressions between Black and White healthy and preeclampsia patients of equivalent BMI and blood pressure in a Southeastern USA cohort 24 samples shares preeclampsia, placental, healthy
- GSE255075 High-throughput sequencing analysis of placental tissue from pregnant women with gestational diabetes and gestational hypertension 9 samples shares placental, pregnant, women
- GSE91077 Global transcriptional profiling confirmed failed decidualization of human Endometrial Stromal Cells (hESCs) obtained from non-pregnant women with a previous pregnancy complicated by severe preeclampsia (sPE). 20 samples shares preeclampsia, pregnant, women
- GSE306864 Placental transcriptome profiles in late-onset preeclampsia: a cross-sectional observational analysis stratified by fetal sex 58 samples shares preeclampsia, placental
- GSE311483 BAP1 dysregulation impairs trophoblast differentiation and contributes to placental dysfunction in preeclampsia 32 samples shares preeclampsia, placental
- GSE287645 Maternal cause of early-onset preeclampsia: excessive endometrial gland-derived apolipoprotein D induces placental ferroptosis and developmental abnormalities 16 samples shares preeclampsia, placental
- GSE290578 Searching for the influencers among placental immune cells in preeclampsia. 16 samples shares preeclampsia, placental
- GSE338646 RNA-sequencing analysis of placental tissues from women with and without polycystic ovary syndrome 14 samples shares placental, women
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.