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Single-cell RNA sequencing reveals T and B cell-related immune features in foot and mouth disease virus-infected mice

GSE279768 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/03/12 Platform GPL19057
Summary
T and B lymphocytes protect against foot and mouth disease virus (FMDV). They are essential for long-term immunity and viral clearance, but their immunological features in FMDV infection remain unknown. Here, we performed single-cell RNA sequencing (scRNA-seq) and conducted integrative analyses to determine cell composition, gene expression, cell-cell communication state, and regulatory network of T and B cells in the spleen of FMDV- and mock-infected mice. Our results revealed variational compositions of immune cells on the subsets level. Additionally, we determined the reshaping of several important pathways in T and B cells, such as the inhibition of antigen-presentation capacity. Finally, the remolding of cell-cell communication and regulatory networks was also characterized during FMDV infection. Overall, our research provides valuable insights and abundant resources for understanding the adaptive immune response in FMD.
Published in
Single-cell RNA sequencing reveals T and B cell-related immune features in foot and mouth disease virus-infected mice
Wang Y, Zhang L, Zhang Z et al. · Virulence 2025 · PMID 41144693 · doi:10.1080/21505594.2025.2580141
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Also filed as BioProject PRJNA1174224 and SRA study SRP539239. Searching any of these in the dataset finder brings you back here.

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