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Effect of inhibition of fatty acid beta-oxidation on gene expression of double-negative T cells

GSE279790 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/09/10 Platform GPL34290
Summary
Double negative T cells are a subset of T cells with immunosuppressive functions. Our research found that cellular energy metabolism, especially fatty acid beta oxidation, is closely related to the function of DNT cells. Therefore, we treated DNT cells with Etomoxir, an inhibitor of fatty acid beta oxidation, and performed RNA sequencing. Taken together, our data provides genetic evidence for the regulation of DNT cell survival and function by fatty acid beta oxidation, and allows for further exploration of its inner molecular mechanisms.
Published in
Fatty acid β-oxidation enhances immune regulatory function of double-negative T cells through pSTAT4-OX40 signaling pathway
Wang Z, Jiang Y, Zhou L et al. · Hepatology communications 2025 · PMID 40879484 · doi:10.1097/HC9.0000000000000783
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Also filed as BioProject PRJNA1174693 and SRA study SRP539337. Searching any of these in the dataset finder brings you back here.

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