Proteogenomic analysis reveals a compendium of therapeutic targets for treatment-resistant subtypes of locally advanced cervical cancers
RNA-seq (gene expression) · human · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Cervical cancerThis series is part of our curated briefing on it.
- Samples
- 16 samples: 12 × SCC_patient vs 3 × ADC_patientGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Proteogenomic characterization of molecular and cellular targets for treatment-resistant subtypes in locally advanced cervical cancersMolecular cancer · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE279998_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1175711 and SRA study SRP539998. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 15 samples.
How we read this: 2 replicated groups read from 16 sample titles; they account for 15 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8585384 SCC_patient1 SCC_patient
- GSM8585385 SCC_patient2 SCC_patient
- GSM8585386 SCC_patient3 SCC_patient
- GSM8585387 SCC_patient4 SCC_patient
- GSM8585388 SCC_patient5 SCC_patient
- GSM8585389 SCC_patient6 SCC_patient
- GSM8585390 SCC_patient7 SCC_patient
- GSM8585391 SCC_patient8 SCC_patient
- GSM8585392 SCC_patient9 SCC_patient
- GSM8585393 SCC_patient10 SCC_patient
- GSM8585394 SCC_patient11 SCC_patient
- GSM8585395 SCC_patient12 SCC_patient
- GSM8585396 ADS_patient1
- GSM8585397 ADC_patient1 ADC_patient
- GSM8585398 ADC_patient2 ADC_patient
- GSM8585399 ADC_patient3 ADC_patient
- GSE268607 Insights into Molecular Mechanisms and Therapeutic Potential of Arborvitae Essential Oil (Thuja plicata) on Cervical Cancer Cells 8 samples same disease briefing · shares therapeutic, cervical
- GSE316098 Spatial Transcriptomic Landscape of Invasion Patterns in Human Papillomavirus-Associated Endocervical Adenocarcinoma 186 samples same disease briefing · shares cervical
- GSE303300 Neoadjuvant Immune Checkpoint Blockade Before Chemoradiation for Patients with FIGO Stage IB3–IVA Cervical Squamous Carcinoma: GINECO Window-Of-Opportunity COLIBRI Study 96 samples same disease briefing · shares cervical
- GSE168244 Patient-derived organoids as a platform to study cervical cancer and viral infection 36 samples same disease briefing · shares cervical
- GSE299125 Paracrine Signals from HIV-1 Infected Immune Cells Reprogram Cervical Cancer Pathways 35 samples same disease briefing · shares cervical
- GSE297038 Chemoradiation Reprograms Tumor Cells and Immune Microenvironment In Cervical Cancer [bulk RNA-seq] 34 samples same disease briefing · shares cervical
- GSE275914 RNA sequencing of 31 pre-treatment, primary cervical cancer samples 31 samples same disease briefing · shares cervical
- GSE264492 Transcriptomic analysis reveals Streptococcus agalactiae activation of oncogenic pathways in cervical adenocarcinoma 24 samples same disease briefing · shares cervical
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.