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Bulk RNA-seq of primary keratinocytes treated with IgG from patients with bullous pemphigoid or controls I

GSE280619 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2024/12/04 Platform GPL20301
Summary
While antibodies in bullous pemphigoid (BP) are known to activate innate immune response, their direct effect on keratinocytes and the overall contribution of keratinocytes to disease pathogenesis is largely unknown. We sought to understand the mechanism of keratinocyte response to autoantibodies in BP. We affinity purified IgG from patients with a known diagnosis of bullous pemphigoid or healthy controls, and performed bulk RNA-seq. We identified numerous differentially expressed genes including upregulation of CXCL16, IL-24, and TGFB1 in BP-IgG treated keratinocytes
Published in
IgG autoantibodies in bullous pemphigoid induce a pathogenic MyD88-dependent pro-inflammatory response in keratinocytes
Bao L, Guerrero-Juarez CF, Li J et al. · Nature communications 2025 · PMID 40769980 · doi:10.1038/s41467-025-62495-2
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Also filed as BioProject PRJNA1179498 and SRA study SRP541864. Searching any of these in the dataset finder brings you back here.

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