GEO series
Intestinal mucosal barrier repair and immune regulation with an AI-developed gut-restricted PHD inhibitor
GSE280622
Mus musculus
Expression profiling by high throughput sequencing
18 samples
2024/12/11
GPL24247
Summary
Hypoxia-inducible factor-prolyl hydroxylase (HIF-PHD) inhibitors have been approved for treating renal anemia, yet have failed clinical testing for inflammatory bowel disease (IBD) due to lack of efficacy. We use a multimodel multimodal generative AI platform to design an orally gut-restricted selective PHD1/2 inhibitor, which exhibits favorable safety and pharmacokinetic profiles in preclinical studies. ISM012-042 restores intestinal barrier function and alleviates gut inflammation in multiple experimental colitis models.
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Paper (PMID 39663371) ↗
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