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The function and mechanisms of hsa_circCDKN2B-AS_012 on tumor suppression of Colorectal cancer

GSE280633 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/10/31 Platform GPL29480Platform GPL11154
Summary
Circular RNAs (circRNAs) are a class of non-coding RNAs with a covalently closed loop structure, which plays crucial roles in regulating tumor development and progression. However, the detailed molecular mechanism of circANRIL in CRC is not fully understood. Real-time quantitative PCR was used to examine the expression of circ86591 in cells. RNA pull-down, mass spectrometry, RNA immunoprecipitation and western blotting were applied to investigate the possible molecule mechanisms of circ86591 and its binding proteins. RNA-sequencing, gain-of-function and loss-of function experiments were performed to find tumor-suppressive effect and the relevant signaling pathways of circ86591.
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Also filed as BioProject PRJNA1179651 and SRA study SRP541927. Searching any of these in the dataset finder brings you back here.

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