GEO series
Detection and monitoring of translocation renal cell carcinoma via plasma cell-free epigenomic profiling
GSE280708
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Other
161 samples
2025/10/31
GPL24676GPL34281
Summary
Translocation renal cell carcinoma (tRCC) is an aggressive fusion-driven subtype of kidney cancer that is frequently misdiagnosed due to morphologic overlap with other kidney cancer subtypes. Conventional liquid biopsy assays targeting DNA alterations are suboptimal for use in tRCC due to its paucity of genomic changes. We demonstrate the utility of cell-free chromatin profiling to noninvasively detect and monitor tRCC with high accuracy, a method that could have applicability to other genomically quiet cancers.
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Paper (PMID 41623182) ↗
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