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Fam170a deficiency causes male infertility

GSE280742 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/11/10 Platform GPL24247
Summary
During spermiogenesis, nucleus condensation packages genomic DNA into tiny sperm heads by histone-to-protamine chromatin remodeling process, which is essential to male fertility. However, this process involving key events and regulators is still poorly understood. Herein, we report that Fam170a orchestrates the histone-to-protamine chromatin remodeling process by interacting with its associated proteins and mediating its associated gene expression.
Published in
Fam170a deficiency causes male infertility by impairing histone-to-protamine exchange during mouse spermiogenesis
Cheng J, Gu Y, Wang Y et al. · Nucleic acids research 2025 · PMID 39868537 · doi:10.1093/nar/gkaf023
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Also filed as BioProject PRJNA1180445 and SRA study SRP542313. Searching any of these in the dataset finder brings you back here.

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