← BioTransfer GEO Dataset Finder
GEO series

Effects of CREB5 overexpression on gene expression in Hepatocellular Carcinoma HepG2 cells

GSE280778 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/02/12 Platform GPL24676
Summary
In order to investigate the role of CREB5 in HCC cells and find its downstream targets, we overexpressed CREB5 by lentiviral technique and established a stable overexpressed CREB5 hepG2 cell line. Then, two groups of cells (n=3), the control group and the overexpressed group, were used for gene expression profiling.
Published in
Endoplasmic reticulum stress-related super enhancer promotes epithelial-mesenchymal transformation in hepatocellular carcinoma through CREB5 mediated activation of TNC
Wang A, Yan S, Liu J et al. · Cell death & disease 2025 · PMID 39915455 · doi:10.1038/s41419-025-07356-y
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE280778_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1180522 and SRA study SRP542361. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.