Combined blockade of CXCR4 and PD1 enhances intratumoral dendritic cell activation and immune responses against hepatocellular carcinoma
RNA-seq (gene expression) · mouse · 10 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 10 samples: 3 × Control vs 3 × Combined Anti-CXCR4 and Anti-PD1 vs 2 × Anti-PD1 vs 2 × Anti-CXCR4Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Combination CXCR4 and PD-1 Blockade Enhances Intratumoral Dendritic Cell Activation and Immune Responses Against Hepatocellular CarcinomaCancer immunology research · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE280861_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1180931 and SRA study SRP542606. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 10 samples.
How we read this: 4 replicated groups read from 10 sample titles; they account for 10 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8606651 Control Rep1 Control
- GSM8606652 Control Rep2 Control
- GSM8606653 Control Rep3 Control
- GSM8606654 Anti-PD1 Rep1 Anti-PD1
- GSM8606655 Anti-PD1 Rep2 Anti-PD1
- GSM8606656 Anti-CXCR4 Rep1 Anti-CXCR4
- GSM8606657 Anti-CXCR4 Rep2 Anti-CXCR4
- GSM8606658 Combined Anti-CXCR4 and Anti-PD1 Rep1 Combined Anti-CXCR4 and…
- GSM8606659 Combined Anti-CXCR4 and Anti-PD1 Rep2 Combined Anti-CXCR4 and…
- GSM8606660 Combined Anti-CXCR4 and Anti-PD1 Rep3 Combined Anti-CXCR4 and…
- GSE301139 Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma 12 samples shares pd1, hepatocellular, combined, blockade
- GSE239485 Effects of the C5aR1 blockade, Poly I:C and anti/PD1 combined treatment in the gene expression in LLC tumors 24 samples shares pd1, combined, blockade
- GSE272309 Investigate the role of B cell in response to anti-PD1 + anti-CTLA in hepatocellular carcinoma 21 samples shares pd1, hepatocellular
- GSE250165 PD1 blockade improves survival and CD8+ cytotoxic capacity, without increasing inflammation, during normal microbial experience in old mice 14 samples shares pd1, blockade
- GSE289773 Pyruvate kinase M2 activation reprograms mitochondria in CD8 T cells, enhancing effector functions and efficacy of anti-PD1 therapy 26 samples shares pd1, activation
- GSE242470 Intestinal Akkermansia muciniphila complements the efficacy of PD1 therapy in MAFLD-related hepatocellular carcinoma 16 samples shares pd1, hepatocellular
- GSE337601 XCR1+ and CD11b+ migratory dendritic cells cooperate for the crosspriming of intratumoral CD8+ T cells with a tissue-resident memory phenotype [RNA-Seq] 36 samples shares intratumoral, dendritic
- GSE301140 Dual Programmed Death Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Blockade Promotes Vascular Normalization and Enhances Antitumor Immune Responses in Hepatocellular Carcinoma 18 samples shares hepatocellular, blockade
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.