A microfluidic bone marrow chip for the safety profiling of biologics in pre-clinical drug development
RNA-seq (gene expression) · human · 11 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 11 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A microfluidic bone marrow chip for the safety profiling of biologics in pre-clinical drug developmentCommunications biology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE281012_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1181833 and SRA study SRP543059. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 11 more — browse all 11 samples with per-sample file links →
- GSE287648 ComBO: A combined human bone and lympho-myeloid bone marrow organoid for pre-clinical modelling of haematopoietic disorders 12 samples shares pre-clinical, marrow, bone
- GSE274018 Single-cell Transcriptome and Crosstalk Analysis Reveals Immune Alterations and Key Pathways in the Bone Marrow of Knee Osteoarthritis Patients 77 samples shares marrow, bone
- GSE215052 Transcriptional profiling by 3' digital gene expression of human HSPCs isolated from the bone marrow of fetal, adult or elderly donors 57 samples shares marrow, bone
- GSE278120 Interferon activation in bone marrow long-lived plasma cells in systemic lupus erythematosus 48 samples shares marrow, bone
- GSE248025 Single-cell RNA sequencing of bone marrow celld from patients with paroxysmal nocturnal hemoglobinuria. 46 samples shares marrow, bone
- GSE115656 Alternative splicing analysis of pediatric B-cell acute lymphoblastic leukemia compared to normal bone marrow derived pro-B cells 38 samples shares marrow, bone
- GSE283315 Investigation of the Altered Transcriptomic Dynamics of Bone Marrow Adipose Tissue Under Exogenous Stimuli in the Context of AML Pathogenesis 36 samples shares marrow, bone
- GSE311899 Autologous cell therapy with CD133+ bone marrow-derived stem cells for Asherman Syndrome: a phase 1/2 trial [biopsies] 35 samples shares marrow, bone
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.