The nitrone compound OKN-007 delays motor neuron loss and disease progression in the G93A mouse model of Amyotrophic Lateral Sclerosis
RNA-seq (gene expression) · mouse · 32 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 32 samples: 8 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The nitrone compound OKN-007 delays motor neuron loss and disease progression in the G93A mouse model of amyotrophic lateral sclerosisFrontiers in neuroscience · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE281064_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1181899 and SRA study SRP543110. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 32 samples.
How we read this: 8 replicated groups read from 32 sample titles; they account for 32 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8610170 wt_unt_90_1 wt_unt_90
- GSM8610171 wt_unt_90_2 wt_unt_90
- GSM8610172 wt_unt_90_3 wt_unt_90
- GSM8610173 wt_unt_90_4 wt_unt_90
- GSM8610174 wt_okn_90_5 wt_okn_90
- GSM8610175 wt_okn_90_6 wt_okn_90
- GSM8610176 wt_okn_90_7 wt_okn_90
- GSM8610177 wt_okn_90_8 wt_okn_90
- GSM8610178 tg_unt_90_9 tg_unt_90
- GSM8610179 tg_unt_90_10 tg_unt_90
- GSM8610180 tg_unt_90_11 tg_unt_90
- GSM8610181 tg_unt_90_12 tg_unt_90
- GSM8610182 tg_okn_90_13 tg_okn_90
- GSM8610183 tg_okn_90_14 tg_okn_90
- GSM8610184 tg_okn_90_15 tg_okn_90
- GSM8610185 tg_okn_90_16 tg_okn_90
- GSM8610186 wt_unt_155_1 wt_unt_155
- GSM8610187 wt_unt_155_2 wt_unt_155
- GSM8610188 wt_unt_155_3 wt_unt_155
- GSM8610189 wt_unt_155_4 wt_unt_155
- GSM8610190 wt_okn_155_5 wt_okn_155
- GSM8610191 wt_okn_155_6 wt_okn_155
- GSM8610192 wt_okn_155_7 wt_okn_155
- GSM8610193 wt_okn_155_8 wt_okn_155
- GSM8610194 tg_unt_155_9 tg_unt_155
- GSM8610195 tg_unt_155_10 tg_unt_155
- GSM8610196 tg_unt_155_11 tg_unt_155
- GSM8610197 tg_unt_155_12 tg_unt_155
- GSM8610198 tg_okn_155_13 tg_okn_155
- GSM8610199 tg_okn_155_14 tg_okn_155
- GSM8610200 tg_okn_155_15 tg_okn_155
- GSM8610201 tg_okn_155_16 tg_okn_155
- GSE234245 Multiomic Profile Integration Reveals Early Signatures of Amyotrophic Lateral Sclerosis and Suggests the MAPK Pathway as a Therapeutic Target [RNA-Seq] 79 samples shares amyotrophic, sclerosis, lateral
- GSE275841 MYC-Driven Gliosis Impairs Neuron-Glia Communication in Amyotrophic Lateral Sclerosis 32 samples shares amyotrophic, sclerosis, lateral
- GSE249071 Repurposing niclosamide in mouse models of amyotrophic lateral sclerosis 14 samples shares amyotrophic, sclerosis, lateral
- GSE292832 Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction 10 samples shares amyotrophic, sclerosis, lateral
- GSE234246 Multiomic Profile Integration Reveals Early Signatures of Amyotrophic Lateral Sclerosis and Suggests the MAPK Pathway as a Therapeutic Target 158 samples shares amyotrophic, sclerosis, lateral
- GSE342036 Acute viral infection with influenza A virus and SARS-CoV-2 accelerates the progression of ALS in SOD1G93A mice. 6 samples shares g93a, progression
- GSE283086 Distinct transcriptomic and epigenomic responses of mature oligodendrocytes during disease progression in a mouse model of multiple sclerosis [RNA-seq] 15 samples shares progression, sclerosis
- GSE274954 Role of GPNMB in Foam Cells Formation and Atherosclerosis Progression 12 samples shares progression, sclerosis
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.