GEO series
DNA methylation stochasticity is linked to transcriptional variability and identifies convergent epigenetic disruption across genetically-defined subtypes of AML [scRNAseq]
GSE281087
Homo sapiens
Expression profiling by high throughput sequencing
26 samples
2026/03/09
GPL24676GPL20301
Summary
Epigenetic regulators are frequently mutated in acute myeloid leukemia (AML). We applied the CPEL method to publicly-available ERRBS data to investigate DNA methylation stochasticity in genetic subtypes of AML, and identified transcriptional dysregulation related to methylation entropy using single-cell RNA-seq data.
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Paper (PMID 41838954) ↗
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