The Impact of PPARβ/ agonism/antagonism on human bone-marrow-derived Mesenchymal Stromal Cells
RNA-seq (gene expression) · human · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The PPARβ/Delta-Induced Mesenchymal Stromal Cell Secretome Has Cytoprotective Effects via ANGPTL4 in a Pre-Clinical Model of Acute Lung InflammationFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE281162_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1182579 and SRA study SRP543431. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8611959 MSC_control_replicate_1 MSC_control
- GSM8611960 MSC_agonist_replicate_1 MSC_agonist
- GSM8611961 MSC_antagonist_replicate_1 MSC_antagonist
- GSM8611962 MSC_TNF_replicate_1 MSC_TNF
- GSM8611963 MSC_TNF_agonist_replicate_1 MSC_TNF_agonist
- GSM8611964 MSC_TNF_antagonist_replicate_1 MSC_TNF_antagonist
- GSM8611965 MSC_control_replicate_2 MSC_control
- GSM8611966 MSC_agonist_replicate_2 MSC_agonist
- GSM8611967 MSC_antagonist_replicate_2 MSC_antagonist
- GSM8611968 MSC_TNF_replicate_2 MSC_TNF
- GSM8611969 MSC_TNF_agonist_replicate_2 MSC_TNF_agonist
- GSM8611970 MSC_TNF_antagonist_replicate_2 MSC_TNF_antagonist
- GSM8611971 MSC_control_replicate_3 MSC_control
- GSM8611972 MSC_agonist_replicate_3 MSC_agonist
- GSM8611973 MSC_antagonist_replicate_3 MSC_antagonist
- GSM8611974 MSC_TNF_replicate_3 MSC_TNF
- GSM8611975 MSC_TNF_agonist_replicate_3 MSC_TNF_agonist
- GSM8611976 MSC_TNF_antagonist_replicate_3 MSC_TNF_antagonist
- GSE293174 Impacts of Inorganic Arsenic Exposure on Genetic Stability of Human Mesenchymal Stromal Cells (hMSCs) 38 samples shares mesenchymal, stromal, impact
- GSE231507 Impact of azide metabolic glycoengineering and bioorthogonal click chemistry cell-cell tethering in adipose tissue-derived mesenchymal stromal cells 15 samples shares mesenchymal, stromal, impact
- GSE251807 Investigation of gene expression changes in normal human dermal fibroblasts after exposure to bone marrow mesenchymal stromal cell secretome 32 samples shares mesenchymal, stromal
- GSE216842 Transcriptomic landscape of human primary stromal cells (fibroblasts, endothelial cells and mesenchymal stem cells) upon therapy-induced senescence (genotoxic chemotherapy） 24 samples shares mesenchymal, stromal
- GSE288706 Mesenchymal stromal cells from JAK2V617F myeloproliferative neoplasms support healthy and malignant haematopoiesis in a humanised scaffold model in vivo 12 samples shares mesenchymal, stromal
- GSE310465 Embryonic lineage-specific iPSC-derived mesenchymal stem/stromal cells exhibit different morphology and intrinsic functions 40 samples shares mesenchymal, stromal
- GSE288678 Combinatorial Extracellular Matrix Tissue Chips for Optimizing Mesenchymal Stromal Cell Microenvironment and Manufacturing 24 samples shares mesenchymal, stromal
- GSE241825 Mesenchymal stromal cell reprogramming and aberrant inflammatory signalling in myelofibrosis: insights from single-cell RNA sequencing 21 samples shares mesenchymal, stromal
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.