TFEB and TFE3 regulate STING1-dependent immune responses by controlling type I interferon signaling [AM_NIH_RNASeq_50538]
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- TFEB and TFE3 regulate STING1-dependent immune responses by controlling type I interferon signalingAutophagy · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE281234_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1182776 and SRA study SRP543658. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8615416 01_NC-Control-01
- GSM8615417 02_NC-Control-02
- GSM8615418 03_NC-Control-03
- GSM8615419 04_2KO-Control-01
- GSM8615420 05_2KO-Control-02
- GSM8615421 06_2KO-Control-03
- GSM8615422 07_NC-DMX-01
- GSM8615423 08_NC-DMX-02
- GSM8615424 09_NC-DMX-03
- GSM8615425 10_2KO-DMX-01
- GSM8615426 11_2KO-DMX-02
- GSM8615427 12_2KO-DMX-03
- GSE281221 TFEB and TFE3 regulate STING1-dependent immune responses by controlling type I interferon signaling [Q48645_RNAseq] 6 samples shares tfeb, tfe3, sting1-dependent, controlling, interferon, regulate
- GSE281183 TFEB and TFE3 regulate STING1-dependent immune responses by controlling type I interferon signaling 2 samples shares tfeb, tfe3, sting1-dependent, controlling, interferon, regulate
- GSE270594 TFEB and TFE3 are key regulators of melanoma biology 24 samples shares tfeb, tfe3
- GSE327962 Effects of CRISPR-mediated knockout of Mitf, Tfe3 and Tfeb on the transcriptome of mouse BMDMs from WT and Grn KO animals [hex001130] 16 samples shares tfeb, tfe3
- GSE284169 SFPQ-TFE3 gene fusion reciprocally regulates mTORC1 activity and induces lineage plasticity in a novel mouse model of renal tumorigenesis 18 samples shares tfe3, regulate
- GSE268530 Angelicin regulated NIH3T3 activity by stimultate by TGF-β and H2O2 6 samples shares nih, regulate
- GSE270826 AMPK promotes TFEB transcriptional activity through dephosphorylation at both mTORC1-dependent and -independent sites 48 samples shares tfeb
- GSE270825 AMPK promotes TFEB transcriptional activity through dephosphorylation at both mTORC1-dependent and -independent sites [dataset 2] 24 samples shares tfeb
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.