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Transcriptome Analysis of Corneal Endothelial Cells in Col8a2Q455K/Q455K/Tcf4+/- compared to Col8a2Q455K/Q455K FECD Mouse Model

GSE281330 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/04/16 Platform GPL24247
Summary
This study investigated transcriptional changes in corneal endothelial cells with and without Tcf4 heterozygous knockout in Col8a2Q455K/Q455K FECD mouse model. RNA-seq analysis was performed on corneal endothelial cells isolated from Col8a2Q455K/Q455K and Col8a2Q455K/Q455K/Tcf4+/- mice. Principal component analysis and hierarchical clustering demonstrated distinct gene expression patterns between the two groups, identifying 1,053 differentially expressed genes. These genes showed significant changes in pathways related to ion transport and TNF signaling.
Published in
Heterozygous Tcf4 Deficiency Mitigates Fuchs Endothelial Corneal Dystrophy Progression in a Mouse Model
Ito S, Oyama Y, Yuasa T et al. · Investigative ophthalmology & visual science 2025 · PMID 40197778 · doi:10.1167/iovs.66.4.19
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Also filed as BioProject PRJNA1183393 and SRA study SRP543849. Searching any of these in the dataset finder brings you back here.

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