Definitive Evidence for the Identification and Function of Renin-Expressing Cholinergic Neurons in the Nucleus Ambiguus
RNA-seq (gene expression) · mouse · 21 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 21 samples: 6 × KO_Male vs 6 × KO_Female vs 5 × WT_Male vs 4 × WT_FemaleGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Definitive Evidence for the Identification and Function of Renin-Expressing Cholinergic Neurons in the Nucleus AmbiguusHypertension (Dallas, Tex. : 1979) · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE281444_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1183868 and SRA study SRP544099. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 21 samples.
How we read this: 4 replicated groups read from 21 sample titles; they account for 21 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8620875 KO_Male_rep1 KO_Male
- GSM8620876 KO_Male_rep2 KO_Male
- GSM8620877 KO_Male_rep3 KO_Male
- GSM8620878 KO_Male_rep4 KO_Male
- GSM8620879 KO_Male_rep5 KO_Male
- GSM8620880 KO_Male_rep6 KO_Male
- GSM8620881 KO_Female_rep2 KO_Female
- GSM8620882 KO_Female_rep3 KO_Female
- GSM8620883 KO_Female_rep4 KO_Female
- GSM8620884 KO_Female_rep5 KO_Female
- GSM8620885 KO_Female_rep6 KO_Female
- GSM8620886 KO_Female_rep1 KO_Female
- GSM8620887 WT_Male_rep1 WT_Male
- GSM8620888 WT_Male_rep2 WT_Male
- GSM8620889 WT_Male_rep3 WT_Male
- GSM8620890 WT_Male_rep4 WT_Male
- GSM8620891 WT_Male_rep5 WT_Male
- GSM8620892 WT_Female_rep1 WT_Female
- GSM8620893 WT_Female_rep2 WT_Female
- GSM8620894 WT_Female_rep3 WT_Female
- GSM8620895 WT_Female_rep4 WT_Female
- GSE252967 Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease 20 samples shares cholinergic, neurons
- GSE328896 Patch-seq analysis of dorsal striatum cholinergic interneurons in a mouse model of 22q11 deletion syndrome 125 samples shares cholinergic, neurons
- GSE296095 Benefits of Maternal choline supplementation on aged basal forebrain cholinergic neurons in a mouse model of Down syndrome and Alzheimer’s disease 44 samples shares cholinergic, neurons
- GSE94010 Neural circuit-specialized astrocytes: genomic, proteomic, morphological and functional evidence 16 samples shares evidence
- GSE277662 Novel insights into Emx2 and Dmrta2 cooperation during cortex development and evidence for Dmrta2 function in choroid plexus 10 samples shares evidence
- GSE297457 A role for the cholinergic neuron circadian clock in RNA metabolism and mediating neurodegeneration 44 samples shares cholinergic
- GSE262620 Hepatic Yap1 activates systemic catabolism and muscle loss during organ repair: evidence for a common mechanism with cancer cachexia 36 samples shares evidence
- GSE269127 Global transcriptomic comparisons between fetal liver and bone marrow definitive erythropoiesis 36 samples shares definitive
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.