Hepatic Yap1 activates systemic catabolism and muscle loss during organ repair: evidence for a common mechanism with cancer cachexia
RNA-seq (gene expression) · mouse · 36 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 36 samples: 8 conditions, mostly with about 5 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE262620_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1092656 and SRA study SRP498193. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 36 samples.
How we read this: 8 replicated groups read from 36 sample titles; they account for 36 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8172506 Liver_Control_1 Liver_Control
- GSM8172507 Liver_Control_2 Liver_Control
- GSM8172508 Liver_Control_3 Liver_Control
- GSM8172509 Liver_PHx_DAY1_1 Liver_PHx_DAY1
- GSM8172510 Liver_PHx_DAY1_2 Liver_PHx_DAY1
- GSM8172511 Liver_PHx_DAY1_3 Liver_PHx_DAY1
- GSM8172512 Liver_PHx_DAY1_4 Liver_PHx_DAY1
- GSM8172513 Liver_PHx_DAY1_5 Liver_PHx_DAY1
- GSM8172514 Liver_PHx_DAY3_1 Liver_PHx_DAY3
- GSM8172515 Liver_PHx_DAY3_2 Liver_PHx_DAY3
- GSM8172516 Liver_PHx_DAY3_3 Liver_PHx_DAY3
- GSM8172517 Liver_PHx_DAY3_4 Liver_PHx_DAY3
- GSM8172518 Liver_PHx_DAY3_5 Liver_PHx_DAY3
- GSM8172519 Liver_PHx_DAY7_1 Liver_PHx_DAY7
- GSM8172520 Liver_PHx_DAY7_2 Liver_PHx_DAY7
- GSM8172521 Liver_PHx_DAY7_3 Liver_PHx_DAY7
- GSM8172522 Liver_PHx_DAY7_4 Liver_PHx_DAY7
- GSM8172523 Liver_PHx_DAY7_5 Liver_PHx_DAY7
- GSM8172524 Quad_Control_1 Quad_Control
- GSM8172525 Quad_Control_2 Quad_Control
- GSM8172526 Quad_Control_3 Quad_Control
- GSM8172527 Quad_PHx_DAY1_1 Quad_PHx_DAY1
- GSM8172528 Quad_PHx_DAY1_2 Quad_PHx_DAY1
- GSM8172529 Quad_PHx_DAY1_3 Quad_PHx_DAY1
- GSM8172530 Quad_PHx_DAY1_4 Quad_PHx_DAY1
- GSM8172531 Quad_PHx_DAY1_5 Quad_PHx_DAY1
- GSM8172532 Quad_PHx_DAY3_1 Quad_PHx_DAY3
- GSM8172533 Quad_PHx_DAY3_2 Quad_PHx_DAY3
- GSM8172534 Quad_PHx_DAY3_3 Quad_PHx_DAY3
- GSM8172535 Quad_PHx_DAY3_4 Quad_PHx_DAY3
- GSM8172536 Quad_PHx_DAY3_5 Quad_PHx_DAY3
- GSM8172537 Quad_PHx_DAY7_1 Quad_PHx_DAY7
- GSM8172538 Quad_PHx_DAY7_2 Quad_PHx_DAY7
- GSM8172539 Quad_PHx_DAY7_3 Quad_PHx_DAY7
- GSM8172540 Quad_PHx_DAY7_4 Quad_PHx_DAY7
- GSM8172541 Quad_PHx_DAY7_5 Quad_PHx_DAY7
- GSE290031 Very long-chain ceramides in skeletal muscle associate with systemic insulin resistance independent of obesity 92 samples shares systemic, muscle
- GSE305924 Systemic toxicity in hepatic Propionyl-CoA Carboxylase deficiency 24 samples shares systemic, hepatic
- GSE285121 The fungicide propiconazole induces hepatic steatosis and activates PXR in a mouse model of diet-induced obesity 24 samples shares activates, hepatic
- GSE307570 Localized FLASH Radiotherapy Reduces Long-Term Skin and Muscle Damage While Preserving Systemic Homeostasis 20 samples shares systemic, muscle
- GSE297387 Nanoengineered STING Mucosal Adjuvant Activates Coordinated Mucosal-Systemic Immunity for Durable Cross-Protective Defense 24 samples shares activates, systemic
- GSE274111 Effect of the depletion of YAP1 in adult spinal cord neural stem cells 20 samples shares yap1
- GSE274930 ZMAT1 promotes osteoclast formation and bone loss through TRIM46 mediated YAP1 degradation II 18 samples shares yap1
- GSE269006 YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1 mediated reprogramming of bone mesenchymal stem cells [RNA-seq] 15 samples shares yap1
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.