GEO series
Adenosine to Inosine RNA editing level in ADAR1-deficient or hypoxia-exposed human pulmonary artery endothelial cells
GSE281541
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2025/10/08
GPL11154
Summary
Hypoxia is a PH trigger which significantly downregulates ADAR1 and reduces A-to-(I)G editing in human PAECs. By RNA sequencing of PAECs after ADAR1 knockdown, we have identified the circadian gene Nocturnin (NOCT) as a direct ADAR1 target. NOCT carries two active A-to-I RNA editing sites in the 3’UTR. In addition, hypoxia significantly reduced A-to-G editing in human PAECs
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Paper (PMID 41342206) ↗
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