Adenosine to Inosine RNA editing level in ADAR1-deficient or hypoxia-exposed human pulmonary artery endothelial cells
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 3 × Hu-siNC vs 3 × Hu-siADAR1 vs 3 × Hu_Nx vs 3 × Hu_HxGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Endothelial ADAR1 Deficit Induces the NOCT-IRF7 Axis in Pulmonary HypertensionCirculation research · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE281541_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1184349 and SRA study SRP544351. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8623115 Hu-siNC_1 Hu-siNC
- GSM8623116 Hu-siNC_2 Hu-siNC
- GSM8623117 Hu-siNC_3 Hu-siNC
- GSM8623118 Hu-siADAR1_1 Hu-siADAR1
- GSM8623119 Hu-siADAR1_2 Hu-siADAR1
- GSM8623120 Hu-siADAR1_3 Hu-siADAR1
- GSM8623121 Hu_Nx1 Hu_Nx
- GSM8623122 Hu_Nx2 Hu_Nx
- GSM8623123 Hu_Nx3 Hu_Nx
- GSM8623124 Hu_Hx1 Hu_Hx
- GSM8623125 Hu_Hx2 Hu_Hx
- GSM8623126 Hu_Hx3 Hu_Hx
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.